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Science 15 September 1972:
Vol. 177. no. 4053, pp. 998 - 1000
DOI: 10.1126/science.177.4053.998
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Articles

Control of Carcinogenesis: A Possible Role for the Activated Macrophage

John B. Hibbs Jr. 1, Lewis H. Lambert Jr. 2, and Jack S. Remington 1

1 Division o] Allergy, Imnmnuinology, and Infectious Diseases, Palo AIto Medical Research Foundationi, Palo Alto, Californzia 94301, and Division of Inifectious Diseases. Department of Medicine, Stanford Uniiversity School of Medicine. Palo A Ito 94305
2 Division o] Allergy, Imnmnuinology, and Infectious Diseases, Palo AIto Medical Research Foundationi, Palo Alto, Californzia 94301, and Division of Inifectious Diseases. Departmnent of Medicine, Stanford Uniiversity School of Medicine. Palo A Ito 94305

Cytotoxic activity of activated mouse macrophages against mouse embryo fibroblasts was tested before and after spontaneous transformation of the fibroblasts in vitro. Activated macrophages caused little or no destruction of untransformed fibroblasts but were markedly cytotoxic to the same fibroblasts after spontaneous transformation. The efferent limb of this cytotoxic reaction appears to be nonimmunologic and to be related to abnormal growth properties rather than to the antigenic composition of target cells.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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Interferon-gamma: the major mediator of resistance against Toxoplasma gondii.
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Macrophage cytotoxicity: role for L-arginine deiminase and imino nitrogen oxidation to nitrite.
J. Hibbs Jr, R. Taintor, and Z Vavrin (1987)
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Defective Monocyte Chemotaxis in Patients With Epidermoid Tumors of the Head and Neck.
R. J. Walter and J. R. Danielson (1985)
Arch Otolaryngol Head Neck Surg 111, 538-540
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A new role for DNA virus early proteins in viral carcinogenesis.
A. Lewis Jr and J. Cook (1985)
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Interferon: an inducer of macrophage activation by polyanions.
R. Schultz, J. Papamatheakis, and M. Chirigos (1977)
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Immunotherapy and Human Tumor Immunology.
J. L. FAHEY, S. BROSMAN, R. C. OSSORIO, C. O'TOOLE, and J. ZIGHELBOIM (1976)
Ann Intern Med 84, 454-465
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Heterocytolysis by Macrophages Activated by Bacillus Calmette-Guerin: Lysosome Exocytosis into Tumor Cells.
J. B. Hibbs Jr. (1974)
Science 184, 468-471
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Macrophage Nonimmunologic Recognition: Target Cell Factors Related to Contact Inhibition.
J. B. Hibbs Jr. (1973)
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