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Science 15 September 1972:
Vol. 177. no. 4053, pp. 1002 - 1003
DOI: 10.1126/science.177.4053.1002
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Articles

Adenosine 3',5'-Monophosphate and N6-2'-O-Dibutyryl-Adenosine 3',5'-Monophosphate Transport in Cells

Wayne L. Ryan 1 and Mary Ann Durick 1

1 Department of Biochemistry, University of Nebraska College of Medicine, Omaha 68105

Incubation of Strain L cells in 0.15 millimolar adenosine 3',5'-monophosphate (cyclic AMP) increase the intracellular level of cyclic AMP more than does incubation in dibutyryl cyclic AMP. The intracellular increase of cyclic AMP is greater with Strain L than with WI-38 cells. Similarly, cell division of Strain L cells is inhibited more by cyclic AMP. The experiments do not, support the belief that dibutyryl cyclic AMP is transported better than cyclic AMP.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)