Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 1 September 1972:
Vol. 177. no. 4051, pp. 809 - 811
DOI: 10.1126/science.177.4051.809
Prev | Table of Contents | Next

Articles

Dibutyryl Cyclic Adenosine Monophosphate Stimulation of Colcemid-Inhibited Axonal Elongation

Fred J. Roisen 1, Richard A. Murphy 1, and Wanda G. Braden 1

1 Department of Anatomy, College of Medicine and Dentistry of New Jersey, Rutgers Medical School, New Brunswick 08903

Adenosine 3',5'-monophosphate (cyclic AMP) and its dibutyryl derivative induce a variety of morphological changes, including those associated with in vitro axonal maturation. Established sensory ganglia treated with dibutyryl cyclic AMP show significant increases in average axonal length and number in comparison with controls; those treated with maintenance doses of Colcemid show no increases in either parameter; simultaneous treatment with both agents results in growth statistically similar to that produced by dibutyryl cyclic AMP alone. The data are consistent with our hypothesis that cyclic AMP promotes axonal elongation by stimulating microtubule assembly from a preexisting subunit pool.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Major innervation of newborn rat cortex by monoaminergic neurons.
J. Coyle and M. Molliver (1977)
Science 196, 444-447
   Abstract »    PDF »
Nerve Growth Factor: Relationship to the Cyclic AMP System of Sensory Ganglia.
D. B. Hier, B. G. W. Arnason, and M. Young (1973)
Science 182, 79-81
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)