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Science 1 September 1972:
Vol. 177. no. 4051, pp. 795 - 797
DOI: 10.1126/science.177.4051.795
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Articles

Histochemical Phosphorylase Activity in Regenerating Muscle Fibers from Myophosphorylase-Deficient Patients

R. I. Roelofs 1, W. K. Engel 1, and P. B. Chauvin 1

1 Medical Neurology Branch, National Institute of Neurological Diseases and Stroke, Bethesda, Maryland 20014

Fresh frozen sections of mature skeletal muscle fibers from patients with genetically determined "absence" of skeletal muscle phosphorylase (McArdle's disease) have no histochemical phosphorylase activity. That regenerating muscle fibers, in vitro and in vivo, from such patients do have histochemical phosphorylase activity present suggests a loss of enzyme activity with fiber maturity.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
McArdle's Disease : The Unsolved Mystery of the Reappearing Enzyme.
A. Martinuzzi, G. Schievano, A. Nascimbeni, and M. Fanin (1999)
Am. J. Pathol. 154, 1893-1897
   Abstract »    Full Text »    PDF »
Muscle-Type Phosphorylase Activity Present in Muscle Cells Cultured From Three Patients With Myophosphorylase Deficiency.
M. C. Meienhofer, V. Askanas, D. Proux-Daegelen, J.-C. Dreyfus, and W. K. Engel (1977)
Arch Neurol 34, 779-781
   Abstract »    PDF »
Familial Right Bundle-Branch Block, Left Axis Deviation, Complete Heart Block, and Early Death: A Heritable Disorder of Cardiac Conduction.
S. F. SCHAAL, J. SEIDENSTICKER, R. GOODMAN, and C. F. WOOLEY (1973)
Ann Intern Med 79, 63-66
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)