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Science 25 August 1972:
Vol. 177. no. 4050, pp. 707 - 709
DOI: 10.1126/science.177.4050.707
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Articles

Receptors for Histamine Can Be Detected on the Surface of Selected Leukocytes

Kenneth L. Melmon 1, Henry R. Bourne 1, Jacob Weinstein 2, and Michael Sela 2

1 Departments of Medicine and Pharmacology, University of California School of Medicine, San Francisco 94122
2 Department of Chemical Immunology, Weizmann Institute of Science, Rehovot Israel

Histamine insolubilized by chemical linkage via a protein or polypeptide carrier to Sepharose beads cannot penetrate cells. Even so, the resultant histamine-coated Sepharose binds leukocytes selectively. Despite the low molecular weight of histaminie, the binding is via preformed cell membrane receptors and can be specifically and competitively blocked or reversed by antihistamines.


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   Abstract »    Full Text »    PDF »
Modulation of Inflammation and Immunity by Cyclic AMP.
H. R. Bourne, Y. Weinstein, K. L. Melmon, L. M. Lichtenstein, C. S. Henney, and G. M. Shearer (1974)
Science 184, 19-28
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Science. ISSN 0036-8075 (print), 1095-9203 (online)