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Science 25 August 1972:
Vol. 177. no. 4050, pp. 697 - 699
DOI: 10.1126/science.177.4050.697
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Articles

Inhibition of Bacterial Adherence by Secretory Immunoglobulin A: A Mechanism of Antigen Disposal

R. C. Williams 1 and R. J. Gibbons 1

1 Forsyth Dental Center, Harvard School of Dental Medicine, Boston, Massachusetts 02115

Preparations of secretory iminunoglobuilin A (S-IgA) isolated from human parotid fluid specifically inhibited the adherence of Streptococcus strains to epithelial cells. Since bacterial adherence is a prerequisite for colonization of mucous surfaces. S-IgA-mediated inhibition of adherence would limit bacterial colonization. This mechanism can explain how secretory immunoglobulins function in the disposal of bacterial antigens.


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