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Science 18 August 1972:
Vol. 177. no. 4049, pp. 630 - 633
DOI: 10.1126/science.177.4049.630
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Articles

Axonal Transport of Gangliosides in the Goldfish Optic Nerve

David S. Forman 1 and Robert W. Ledeen 2

1 Laboratory of Neuropharmacology, National Institute of Mental Health, Saint Elizabeths Hospital, Washington, D.C. 20032
2 Departments of Neurology and Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461

Radioactive glucosamine and N-acetylmannosamine injected into the goldfish eye are incorporated into gangliosides that undergo rapid axonal transport to the optic nerve terminals. All ganglioside fractions are labeled. These data provide the first evidence that axonal transport has a role in neuronal ganglioside function and metabolism.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Regulation of ganglioside biosynthesis in the nervous system.
R. K. Yu, E. Bieberich, T. Xia, and G. Zeng (2004)
J. Lipid Res. 45, 783-793
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Membrane glycolipids: regional synthesis and axonal transport in a single identified neuron of Aplysia californica.
A. Sherbany, R. Ambron, and J. Schwartz (1979)
Science 203, 78-80
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)