Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 18 August 1972:
Vol. 177. no. 4049, pp. 618 - 619
DOI: 10.1126/science.177.4049.618
Prev | Table of Contents | Next

Articles

Aryl Hydrocarbon (Benzopyrene) Hydroxylase Is Stimulated in Human Lymphocytes by Mitogens and Benz[a]anthracene

James P. Whitlock Jr. 1, Herbert L. Cooper 2, and Harry V. Gelboin 3

1 Chemistry Branch, National Cancer Institute, Bethesda, Maryland 20014
2 Cell Biology Section, Laboratory of Biochemistry, National Institute of Dental Research, Bethesda, Maryland
3 Chemistry Branch, National Cancer Institute, Bethesda, Maryland

A mixed-function oxidase that requires reduced nicotinamide adenine dinucleotide phosphate, is carbon monoxide sensitive, and is drug-metabolizing is present in human lymphocytes and is increased to different levels by treatment with phytohemagglutinin, pokeweed mitogen, and a polycyclic hydrocarbon.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Cytochrome P450 1A1 and 1B1 in Human Blood Lymphocytes Are Not Suitable as Biomarkers of Exposure to Dioxin-like Compounds: Polymorphisms and Interindividual Variation in Expression and Inducibility.
M. B. M. van Duursen, J. T. Sanderson, and M. van den Berg (2005)
Toxicol. Sci. 85, 703-712
   Abstract »    Full Text »    PDF »
Constitutive Activation and Environmental Chemical Induction of the Aryl Hydrocarbon Receptor/Transcription Factor in Activated Human B Lymphocytes.
L. L. Allan and D. H. Sherr (2005)
Mol. Pharmacol. 67, 1740-1750
   Abstract »    Full Text »    PDF »
Quantitative Analysis of Constitutive and 2,3,7,8-Tetrachlorodibenzo-p-dioxin-induced Cytochrome P450 1B1 Expression in Human Lymphocytes.
D. L. Spencer, S. A. Masten, K. M. Lanier, X. Yang, J. A. Grassman, C. R. Miller, T. R. Sutter, G. W. Lucier, and N. J. Walker (1999)
Cancer Epidemiol. Biomarkers Prev. 8, 139-146
   Abstract »    Full Text »
Genetic and Environmental Regulation of Aryl Hydrocarbon Hydroxylase in Man: Studies with Liver, Lung, Placenta, and Lymphocytes.
O. Pelkonen, K. Vahakangas, N. T. Karki, and E. A. Sotaniemi (1984)
Toxicol Pathol 12, 256-260
   Abstract »    PDF »
Aryl hydrocarbon hydroxylase is inhibited by antibody to rat liver cytochrome P-450.
K Robie-Suh, R Robinson, H. Gelboin, and F. Guengerich (1980)
Science 208, 1031-1033
   Abstract »    PDF »
Genetic Variation in Coumarin Hydroxylase Activity in the Mouse (Mus musculus).
A. W. Wood and A. H. Conney (1974)
Science 185, 612-614
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)