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Science 11 August 1972:
Vol. 177. no. 4048, pp. 534 - 535
DOI: 10.1126/science.177.4048.534
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Articles

Facilitation of Recovery by agr-Methyl-p-Tyrosine after Lateral Hypothalamic Damage

Stanley D. Glick 1, Stuart Greenstein 1, and Betty Zimmerberg 1

1 Herbert M. Singer Laboratory of Neurosciences and Addictive Diseases, Bernstein Institute, Beth Israel Medical Center, New York 10003, and Department of Pharmacology, Mount Sinai School of Medicine, New York 10029

Rats with bilateral lateral hypothalamic lesions die of starvation in approximately 7 days after surgery. Rats that were treated with agr-methyl-p-tyrosine for 3 days prior to lateral hypothalamic surgery spontaneously eat, drink, and gain weight after surgery. These data suggest that recovery of function after lateral hypothalamic damage involves denervation supersensitivity.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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Glucodynamic Hormones Modify the Recovery Period after Lateral Hypothalamic Lesions.
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Nerve Growth Factor: Enhanced Recovery of Feeding after Hypothalamic Damage.
B. D. Berger, C. D. Wise, and L. Stein (1973)
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