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Science 4 August 1972:
Vol. 177. no. 4047, pp. 442 - 444
DOI: 10.1126/science.177.4047.442
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Articles

Water-Soluble Derivatives of Dgr1 Tetrahydrocannabinol

B. A. Zitko 1, J. F. Howes 1, R. K. Razdan 1, B. C. Dalzell 1, H. C. Dalzell 1, John C. Sheehan 1, H. G. Pars 1, W. L. Dewey 2, and L. S. Harris 2

1 Sheehan Institute and Sharps Associates, 767-B Concord Avenue, Cambridge, Massachusetts 02138
2 University of North Carolina, Chapel Hill 27514

Dgr1-Tetrahydrocannabinol, which is resinous and insoluble in water and therefore difficult to study pharmacologically, can be converted to a watersoluble derivative without loss of its biological activity. This has been achieved by preparing esters bearing a nitrogen moiety with the use of carbodiimide as the condensing agent. The availability of such water-soluble derivatives will allow the evaluation of Dgr1-tetrahydrocannabinol in self-administration studies in monkeys for its addiction liability potential in man. This technique of water solubilization is also applicable to other compounds of chemical and biological significance.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Pharmacological Characterization of Novel Water-Soluble Cannabinoids.
B. R. Martin, J. L. Wiley, I. Beletskaya, L. J. Sim-Selley, F. L. Smith, W. L. Dewey, J. Cottney, J. Adams, J. Baker, D. Hill, et al. (2006)
J. Pharmacol. Exp. Ther. 318, 1230-1239
   Abstract »    Full Text »    PDF »
Cannabinoid induced behavioral convulsions in rabbits.
P Martin and P Consroe (1976)
Science 194, 965-967
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)