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Science 4 August 1972:
Vol. 177. no. 4047, pp. 433 - 434
DOI: 10.1126/science.177.4047.433
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Articles

Tumor Imunity in vitro: Destruction of a Mouse Ascites Tumor through a Cycling Pathway

Gideon Berke 1, Karen A. Sullivan 1, and D. Bernard Amos 1

1 Department of Microbiology and Immunology, Duke University Medical Center, Durham, North Carolina 27710

Lymphocytes in peritoneal exudate from BALB/c mice immunized against ascites leukemia EL4 are uniquely efficient at destroying 51chromiumlabeled EL4 cells in vitro. The lytic process depends upon the number of lymphocyte-tumor cell interactions. Efector lymphocytes are not inactivated as a result of lethal contact but can interact repeatedly with tumor cells.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)