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Science 14 July 1972:
Vol. 177. no. 4044, pp. 175 - 177
DOI: 10.1126/science.177.4044.175
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Articles

Pitting Function of the Spleen in Malaria: Ultrastructural Observations

Bertram Schnitzer 1, Thomas Sodeman 1, Michael L. Mead 1, and Peter G. Contacos 2

1 Department of Pathology, University of Michigan, Ann Arbor 48104
2 Section on Primate Malaria, Laboratory of Parasitic Diseases, National Institutes of Health, Chamblee, Georgia 30341

Ultrastructural studies of spleens from monkeys infected with Plasmodium knowlesi suggest that the spleen removes or "pits" malaria parasites from red cells. This function may explain the presence of nonparasitized spherocytic erythrocytes in the peripheral blood and may in part account for the discrepancy between the excessive hemolysis and the number of parasitized erythrocytes in animals with experimentally induced malaria.


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Science. ISSN 0036-8075 (print), 1095-9203 (online)