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Science 30 June 1972:
Vol. 176. no. 4042, pp. 1435 - 1437
DOI: 10.1126/science.176.4042.1435
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Articles

Mixed Function Oxidase and Ethanol Metabolism in Perfused Rat Liver

Ilmo E. Hassinen 1 and Reino H. Ylikahri 1

1 Department of Medical Chemistry, University of Helsinki, 00170 Helsinki 17, Finland

Oxidation-reduction changes of cytochrome P-450 and oxygen consumption were measured in isolated perfused livers from normal and phenobarbital-treated rats. Phenobarbital treatment markedly increased the aminopyrine-induced reduction of cytochrome P-450, but ethanol did not cause any redox changes of this cytochrome. It was concluded that the microsomal ethanol-oxidizing system has an insignificant role in the metabolism of ethanol in intact liver.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)