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Science 30 June 1972:
Vol. 176. no. 4042, pp. 1429 - 1431
DOI: 10.1126/science.176.4042.1429
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Articles

Somatic Cell Genetic Assignment of Peptidase C and the Rh Linkage Group to Chromosome A-1 in Man

F. Ruddle 1, F. Ricciuti 1, F. A. McMorris 1, J. Tischfield 1, R. Creagan 1, G. Darlington 1, and T. Chen 1

1 Department of Biology, Kline Biology Tower, Yale University, New Haven, Connecticut 06520

The segregation of the human peptidase-C phenotype in five different series of human-mouse hybrid clones was examined. The chromosome constitution of these hybrids was determined by quinacrine mustard fluorescence, Giemsa banding, and constitutive heterochromatin staining. That the clones could be classified without exception either as human peptidase C positive/ A-1 positive (14 clones), or as peptidase C negative/ A-1 negative (12 clones) indicates that peptidase C can be assigned to the human A-i chromosome. Data from an extensive series of human-mouse clones used provide support for the syntenic association between peptidase C and phosphoglucomutase-1 and by inference a linkage of both to Rh factor group.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The status of the gene map of the human chromosomes.
V. McKusick and F. Ruddle (1977)
Science 196, 390-405
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Mapping Human Autosomes: Evidence Supporting Assignment of Rhesus to the Short Arm of Chromosome No. 1.
W. L. Marsh, R. S. K. Chaganti, F. H. Gardner, K. Mayer, P. C. Nowell, and J. German (1974)
Science 183, 966-968
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