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Science 30 June 1972:
Vol. 176. no. 4042, pp. 1423 - 1425
DOI: 10.1126/science.176.4042.1423
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Articles

Salicylate: A Structure-Activity Study of its Effects on Membrane Permeability

Herbert Levitan 1 and Jeffery L. Barker 1

1 Behavioral Biology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20014

Salicylate atnd benzoate, and their anlalogs, reversibly increase the membrane potetntial and conductance of identified molluscan neurons by increasing potassium conductance and decreasing chloride conductance. The relative potencies of these compounds were closely correlated with their octanol-water partition coefficients and their pKa values.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Diffusion of Weak Acids across Lipid Bilayer Membranes: Effects of Chemical Reactions in the Unstirred Layers.
J. Gutknecht and D. C. Tosteson (1973)
Science 182, 1258-1261
   Abstract »    PDF »
Membrane Permeability: Cation Selectivity Reversibly Altered by Salicylate.
H. Levitan and J. L. Barker (1972)
Science 178, 63-64
   Abstract »    PDF »


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