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Science 23 June 1972:
Vol. 176. no. 4041, pp. 1353 - 1355
DOI: 10.1126/science.176.4041.1353
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Articles

Synaptic Vesicles: Selective Depletion in Crayfish Excitatory and Inhibitory Axons

Harold L. Atwood 1, Fred Lang 1, and Walter A. Morin 2

1 Department of Zoology, University of Toronto, Toronto, Ontario, Canada
2 Department of Biology, State College, Bridgewater, Massachusetts 02324

Stimulation of the excitatory axon of the opener muscle of the crayfish in the presence of the metabolic inhibitor 2,4-dinitrophenol leads to depletion of synaptic vesicles in nerve terminals containing round vesicles. Stimulation of the inhibitory axon under these conditions produces depletion of vesicles in other nerve terminals containing more elongate synaptic vesicles. The experiments show that terminals with round synaptic vesicles are excitatory and that terminals with elongate synaptic vesicles are inhibitory. Replenishment of synaptic vesicles appears to require metabolic energy.


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Science. ISSN 0036-8075 (print), 1095-9203 (online)