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Science 23 June 1972:
Vol. 176. no. 4041, pp. 1337 - 1340
DOI: 10.1126/science.176.4041.1337
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Articles

Immunological Studies on Urinary Bladder Tumors of Rats and Mice

L. A. Taranger 1, W. H. Chapman 1, I. Hellström 1, and K. E. Hellström 1

1 Departments of Pathology, Urology, and Microbiology, University of Washington Medical School, Seattle 98195

Human neoplasms derived from the same tissue have been previously shown to have tumor associated antigens characterizing that tissue type. Evidence is now presented for the existence of analogous antigens common to both rat bladder papillomas and carcinomas, and for antigens common to mouse bladder carcinomas. Rats immunized with syngeneic urinary bladder papillomas, then challenged with a methylcholanthrene pellet inserted into the bladder, develop (4 to 6 months later) fewer primary bladder tumors than rats immunized with normal bladder tissue.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)