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Science 16 June 1972:
Vol. 176. no. 4040, pp. 1245 - 1246
DOI: 10.1126/science.176.4040.1245
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Articles

Hybridization of Burkitt Lymphoblastoid Cells

R. Glaser 1 and F. J. O'Neill 1

1 Department of Microbiology, College of Medicine, Milton S. Hershey Medical Center, Pennsylvania State University, Hershey 17033

Burkitt lymphoblastoid cell lines have been fused to mouse and human cell lines with the use of inactivated Sendai virus. The heterokaryons have developed into somatic cell hybrids of both parental cell types. Chromosome analyses confirm that cells now growing in selective medium are hybrids. Initial observations of preparations of the hybrid cells reveal that 5'-iododeoxyuridine can induce continued synthesis of Epstein-Barr virus antigens by these hybrid cells.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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Cytomegalovirus: Conversion of Nonpermissive Cells to a Permissive State for Virus Replication.
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Science 181, 1060-1061
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Epstein-Barr Virus: Detection of Genome in Somatic Cell Hybrids of Burkitt Lymphoblastoid Cells.
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Science 179, 492-493
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