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Science 9 June 1972:
Vol. 176. no. 4039, pp. 1146 - 1147
DOI: 10.1126/science.176.4039.1146
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Articles

1,25-Dihydroxycholecalciferol: Metabolite of Vitamin D3 Active on Bone in Anephric Rats

M. F. Holick 1, M. Garabedian 1, and H. F. DeLuca 1

1 Department of Biochemistry, College of Agricultural and Life Sciences, University of Wisconsin, Madison 53706

Nephrectomy prevents completely the bone calcium mobilization response to 25-hydroxycholecalciferol. In contrast it does not prevent this response to 1,25-dihydroxycholecalciferol. Because it is known that the kidney is the site of 1,25-dihydroxycholecalciferol formation, these results provide evidence that 1,25-dihydroxycholecalciferol or a further metabolite thereof and not 25-hydroxycholecalciferol is the metabolically active form of vitamin D3 responsible for bone calcium mobilization.


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1{alpha},25-Dihydroxycholecalciferol activates binding of CREB to a CRE site in the CD14 promoter and drives promoter activity in a phosphatidylinositol-3 kinase-dependent manner.
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1{alpha},25-Dihydroxyvitamin D3-induced Myeloid Cell Differentiation Is Regulated by a Vitamin D Receptor-Phosphatidylinositol 3-Kinase Signaling Complex.
Z. Hmama, D. Nandan, L. Sly, K. L. Knutson, P. Herrera-Velit, and N. E. Reiner (1999)
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Current Understanding of the Molecular Actions of Vitamin D.
G. JONES, S. A. STRUGNELL, and H. F. DeLUCA (1998)
Physiol Rev 78, 1193-1231
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Vitamin D Metabolism and Function.
H. F. DeLuca (1978)
Arch Intern Med 138, 836-847
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Vitamin D Endocrinology.
H. F. DeLUCA (1976)
Ann Intern Med 85, 367-377
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Vitamin D Intoxication in an Anephric Child.
S. J. COUNTS, D. J. BAYLINK, F.-H. SHEN, D. J. SHERRARD, and R. O. HICKMAN (1975)
Ann Intern Med 82, 196-200
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Stimulation of 24,25-Dihydroxyvitamin D3 Production by 1,25-Dihydroxyvitamin D3.
Y. Tanaka and H. F. DeLuca (1974)
Science 183, 1198-1200
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Intestinal Calcium Transport: Stimulation by Low Phosphorus Diets.
Y. Tanaka, H. Frank, and H. F. DeLuca (1973)
Science 181, 564-566
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Isotachysterol3 and 25-Hydroxyisotachysterol3: Analogs of 1,25-Dihydroxyvitamin D3.
M. F. Holick, H. F. DeLuca, P. M. Kasten, and M. B. Korycka (1973)
Science 180, 964-966
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1agr-Hydroxy Derivative of Vitamin D3: A Highly Potent Analog of 1agr,25-Dihydroxyvitamin D3.
M. F. Holick, E J. Semmler, H. K. Schnoes, and H. F. Deluca (1973)
Science 180, 190-191
   Abstract »    PDF »
5,6-Trans-25-Hydroxycholecalciferol: Vitamin D Analog Effective on Intestine of Anephric Rats.
M. F. Holick, M. Garabedian, and H. F. DeLuca (1972)
Science 176, 1247-1248
   Abstract »    PDF »


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