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Science 2 June 1972:
Vol. 176. no. 4038, pp. 1043 - 1045
DOI: 10.1126/science.176.4038.1043
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Articles

Gamma-Amiobutyric Acid: Role in Primary Afferent Depolarization

Jeffery L. Barker 1 and Roger A. Nicoll 1

1 Laboratory of Neuropharmacology, National Institute of Mental Health, St. Elizabeths Hospital, Washington, D.C. 20032

The effects of putative transmitters on the primary afferent terminals were studied in the magnesium-treated, isolated spinal cord of the frog. Gamma-aminobutyric acid and glutamic acid reversibly depolarized primary afferent terminals and increased their excitability, whereas glycine produced weak and variable effects. Bicuculline and picrotoxin, which reduce primary afferent depolarization, reversibly antagonized the gamma-aminobutyric acid-mediated responses but had little effect on those produced by either glutamic acid or glycine. The glutamic acid- and the gamma-aminobutyric acid-induced depolarizations remained in the absence of external chloride but disappeared in the absence of external sodium. These results support the hypotheses that gamma-aminobutyric acid is the transmitter mediating the synaptic depolarization of primary afferent terminals and that sodium is the predominant ion involved.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Development of specific sensory-evoked synaptic networks in fetal mouse cord-brainstem cultures.
S. Crain and E. Peterson (1975)
Science 188, 275-278
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Science. ISSN 0036-8075 (print), 1095-9203 (online)