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Science 2 June 1972:
Vol. 176. no. 4038, pp. 1029 - 1031
DOI: 10.1126/science.176.4038.1029
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Articles

Biosynthesis of C4 (Fourth Component of Complement) by Hybrids of C4-Deficient Guinea Pig Cells and HeLa Cells

Harvey R. Colten 1 and Robertson Parkman 1

1 Immunology Division, Department of Medicine, Children's Hospital Medical Center, and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02115

Peritoneal exudate cells from guinea pigs homozygous for a genetic deficiency of the fourth component of complement (C4) were fused in vitro with a cell line of human origin (HeLa). The resulting hybrid cells, derived from cell lines each incapable of C4 synthesis by themselves, synthesized functionally active human C4.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Genetic defect in biosynthesis of the precursor form of the fourth component of complement..
R. E. HALL and H. R. COLTEN (1978)
Science 199, 69-70
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Science. ISSN 0036-8075 (print), 1095-9203 (online)