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Science 2 June 1972:
Vol. 176. no. 4038, pp. 1024 - 1027
DOI: 10.1126/science.176.4038.1024
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Articles

Genetic and Immunological Complexity of Major Histocompatibility Regions

Fritz H. Bach 1, Michael B. Widmer 1, Miriam Segall 1, Marilyn L. Bach 2, and Jan Klein 3

1 Departments of Medical Genetics and Medicine, University of Wisconsin, Madison 53706
2 Departments of Pediatrics and Pharmacology, University of Wisconsin, Madison
3 Departments of Oral Biology and Hutman Genetics, University of Michigan, Ann Arbor

There are genetic differences within the major histocompatibility complex of the mouse which lead to skin graft rejection but which cannot be detected serologically. When confronted with these differences on allogeneic cells, lymphocytes proliferate in vitro. In other cases, in vitro lymphocyte proliferation but no skin graft rejection is associated with loci that are linked to but genetically separable from the loci controlling the serologically defined antigens.


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