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Science 19 May 1972:
Vol. 176. no. 4036, pp. 805 - 806
DOI: 10.1126/science.176.4036.805
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Articles

Insulin Receptor of Fat Cells in Insulin-Resistant Metabolic States

G. Vann Bennett 1 and Pedro Cuatrecasas 1

1 Departments of Medicine and Pharmacology and Experimental Therapeutics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205

A diminished response to insulin is exhibited by isolated fat cells obtained from rats that have been either starved, or treated with prednisone, or made diabetic by administration of streptozotocin. This decrease in response is not accompanied by changes in the quantity of insulin receptor of these cells or in the affinity of these receptors for insulin. Similarly, the decreased responsiveness to insulin of fat cells obtained from certain species (hamster, rabbit, mouse, guinea pig) is not explainable in terms of alterations of the insulin receptor.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Insulin receptor: role in the resistance of human obesity to insulin.
J. Amatruda, J. Livingston, and D. Lockwood (1975)
Science 188, 264-266
   Abstract »    PDF »
Biological Activity of Insulin-Sepharose?.
H. M. Katzen, G. J. Vlahakes, and P. Cuatrecasas (1973)
Science 179, 1142-1144
   PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)