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Science 19 May 1972:
Vol. 176. no. 4036, p. 795
DOI: 10.1126/science.176.4036.795
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Articles

Hepatic Collagen Metabolism: Effect of Alcohol Consumption in Rats and Baboons

Lawrence Feinman 1 and Charles S. Lieber 1

1 Department of Medicine, Mount Sinai School of Medicine, City University of New York, and Section of Liver Disease and Nutrition, Veterans Administration Hospital, Bronx, New York 10468

Long-term ethanol feeding causes collagen accumulation in livers of rats and baboons. Activity of collagen proline hydroxylase in the liver is also stimulated, and incorporation of proline into collagen hydroxyproline in rat liver slices is significantly enhanced, a result indicating that increased synthesis is responsible, in part, for the collagen accumulation.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Effects of Alcohol on the Heart: Current Views.
G. Kouvaras and D. Cokkinos (1986)
Angiology 37, 592-600
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Alcohol and Malnutrition in the Pathogenesis of Liver Disease.
C. S. Lieber (1975)
JAMA 233, 1077-1082
   Abstract »    PDF »
Alcohol and the Liver.
C. STOUT (1974)
Ann Intern Med 81, 124-125
   Abstract »    PDF »
Fibrogenic Effect of Alcohol in Rat Liver: Role of Diet.
W. S. Hartroft, E. A. Porta, L. Feinman, and C. S. Lieber (1973)
Science 179, 406-407
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Science. ISSN 0036-8075 (print), 1095-9203 (online)