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Science 12 May 1972:
Vol. 176. no. 4035, pp. 686 - 687
DOI: 10.1126/science.176.4035.686
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Articles

Pregnancy Suppression by an Antiserum to the Sperm Specific Lactate Dehydrogenase

Erwin Goldberg 1 and Jerrold Lerum 1

1 Department of Biological Sciences, Northwestern University, Evanston, Illinois 60201

An antiserum induced against the isozyme of lactate dehydrogenase (LDH-X) that is unique to spermatozoa reduced significantly the number of pregnancies in mice treated at varying times after they had mated. This effect of the antiserum occurred both prior to and following implantation. The fecundity of treated animals appeared to be normal in subsequent matings.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Lactate dehydrogenase X: effects of antibody on mouse gametes but not on early development.
R. Erickson, P. Hoppe, D Tennenbaum, H Spielmann, and C. Epstein (1975)
Science 188, 261-263
   Abstract »    PDF »
Infertility in Female Rabbits Immunized with Lactate Dehydrogenase X.
E. Goldberg (1973)
Science 181, 458-459
   Abstract »    PDF »
Inhibition of Sperm-Egg Interaction by Specific Antibody.
C. A. Shivers, A. B. Dudkiewicz, L. E. Franklin, and E. N. Fussell (1972)
Science 178, 1211-1213
   Abstract »    PDF »


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