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Science 5 May 1972:
Vol. 176. no. 4034, pp. 530 - 532
DOI: 10.1126/science.176.4034.530
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Articles

Synaptogenesis in the Rat Cerebellum: Effects of Early Hypo- and Hyperthyroidism

Jean L. Nicholson 1 and Joseph Altman 1

1 Laboratory of Developmental Neurobiology, Department of Biological Sciences, Purdue University, Lafayette, Indiana 47906

The number of synapses in the molecular layer of the rat cerebellum is reduced by early hypo-and hyperthyroidism within 30 days. Hypothyroidism retards synaptogenesis after 10 days, while hyperthyroidism accelerates synaptogenesis initially, but by 21 days the number of synapses is reduced. The sensitivity of developing synapses to thyroid hormone may permit analysis of the events triggering synaptogenesis.


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