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Science 28 April 1972:
Vol. 176. no. 4033, pp. 428 - 430
DOI: 10.1126/science.176.4033.428
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Articles

Cyclic Adenosine Monophosphate Phosphodiesterase in Brain: Effect on Anxiety

Bernard Beer 1, Mark Chasin 1, Donald E. Clody 1, John R. Vogel 1, and Zola P. Horovitz 1

1 Squibb Institute for Medical Research, New Brunswick, New Jersey 08903

Drugs that reduce anxiety may be mediated by cyclic adenosine monophosphate in the brain because (i) potent anxiety-reducing drugs are also potent inhibitors of brain phosphodiesterase activity; (ii) dibutyryl cyclic adenosine monophosphate has the ability to reduce anxiety; (iii) the methylxanthines show significant anxiety-reducing effects; (iv) theophylline and chlordiazepoxide produce additive anxiety-reducing activity; and (v) there is a significant correlation between the anxiety-reducing property of drugs and their ability to inhibit phosphodiesterase activity in the brain.


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