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Science Signaling - Call For Papers

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Science 28 April 1972:
Vol. 176. no. 4033, pp. 419 - 420
DOI: 10.1126/science.176.4033.419
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Articles

Induction of Benzo[agr]pyrene Hydroxylase in Human Skin

W. Levin 1, A. H. Conney 1, A. P. Alvares 2, I. Merkatz 2, and A. Kappas 2

1 Department of Biochemistry and Drug Metabolism, Hoffmann-La Roche Inc., Nutley, New Jersey 07110
2 Rockefeller University and Cornell University Medical College, New York 10021

Foreskins from children who were circumcised 2 to 4 days after birth contain an enzyme system that hydroxylates the carcinogen benzo[agr]pyrene. When foreskin was cultured for 16 hours in the presence of 10 micromolar benz[agr]anthracene, a two- to fivefold increase in activity of benzo[agr]pyrene hydroxylase was obtained. An evaluation of the basal activity and inducibility of carcinogen-metabolizing enzymes in human tissues may provide a means of determining the ability of different individuals to metabolize carcinogens.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Differentiation-Specific Factors Modulate Epidermal CYP1-4 Gene Expression in Human Skin in Response to Retinoic Acid and Classic Aryl Hydrocarbon Receptor Ligands.
L. Du, M. M. Neis, P. A. Ladd, and D. S. Keeney (2006)
J. Pharmacol. Exp. Ther. 319, 1162-1171
   Abstract »    Full Text »    PDF »
Metabolic Interactions Among Environmental Chemicals and Drugs: Environmental chemicals that alter microsomal activity may influence the safety and efficacy of drugs.
A. H. Conney and J. J. Burns (1972)
Science 178, 576-586
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)