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Science 21 April 1972:
Vol. 176. no. 4032, pp. 305 - 306
DOI: 10.1126/science.176.4032.305
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Articles

A Calcium Pump in Vascular Smooth Muscle

David F. Fitzpatrick 1, Erwin J. Landon 1, Gamil Debbas 1, and Leon Hurwitz 1

1 Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37203

A microsomal cell fraction derived from the intimal-medial layer of rabbit aorta takes up calcium in the presence of magnesium and adenosine triphosphate. The rate of uptake of calcium is slower than that observed in skeletal muscle microsomes. Uptake of calcium by mitochondria from the aorta is even more limited and, unlike microsomal uptake, is inhibited by azide.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Localization of Acid and Alkaline Phosphatase Activities in the Blood Vessels of Normotensive and Hypertensive Rats.
T. Alan Twietmeyer, J. A. Maynard, and R. C. Bhalla (1979)
Angiology 30, 317-326
   PDF »
Localization of Calcium Pump Activity in Smooth Muscle.
L. Hurwitz, D. F. Fitzpatrick, G. Debbas, and E. J. Landon (1973)
Science 179, 384-386
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)