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Science 21 April 1972:
Vol. 176. no. 4032, pp. 298 - 299
DOI: 10.1126/science.176.4032.298
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Articles

Induction of Pulmonary Edema and Emphysema in Cattle and Goats with 3-Methylindole

J. R. Carlson 1, M. T. Yokoyama 1, and E. O. Dickinson 1

1 Departments of Animal Sciences and Veterinary Pathology, Washington State University, Pullman 99163

Microorganisms from rumen converted L-tryptophan and indoleacetic acid to 3-methylindole in vitro. Oral doses of 3-methylindole caused interstitial pulmonary edema and emphysema in cattle and goats. Intravenous infusion of this metabolite also induced pulmonary disease in cattle. These results demonstrate than an end product of ruminal fermentation of tryptophan can induce acute pulmonary disease in cattle and goats.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
3-Methylindole Induces Transient Olfactory Mucosal Injuryin Ponies.
M. A. Miller, S. J. Kottler, J. A. Ramos-Vara, P. J. Johnson, V. K. Ganjam, and T. J. Evans (2003)
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Identification of Phase I Metabolites of 3-Methylindole Produced by Pig Liver Microsomes.
G. J. Diaz, K. W. Skordos, G. S. Yost, and E. J. Squires (1999)
Drug Metab. Dispos. 27, 1150-1156
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Monensin and the prevention of tryptophan-induced acute bovine pulmonary edema and emphysema.
A. Hammond, Carlson JR, and R. Breeze (1978)
Science 201, 153-155
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Science. ISSN 0036-8075 (print), 1095-9203 (online)