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Science 21 April 1972:
Vol. 176. no. 4032, pp. 292 - 294
DOI: 10.1126/science.176.4032.292
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Articles

Synergy of Ethanol and Putative Neurotransmitters: Glycine and Serine

Kenneth Blum 1, Jack E. Wallace 2, and Irving Geller 3

1 Department of Pharmacology, University of Texas Medical School, San Antonio 78229
2 Forensic Toxicology Branch, School of Aerospace Mediciee, Brooks Air Force Base, Texas 78235
3 Department of Experimental Pharmacology, Southwest Foundation for Research and Education, San Antonio, Texas 78228

The putative neurotransmitters, glycine and serine, significantly enhanced the sleeping time (loss of the righting reflex) that was induced by ethanol in mice. The observed synergistic effect between ethanol and the amino acids is probably not related to an alteration of ethanol metabolism, but rather to an interaction of these compounds in the central nervous system.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)