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Science 14 April 1972:
Vol. 176. no. 4031, pp. 189 - 191
DOI: 10.1126/science.176.4031.189
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Articles

Acetylcholine Receptors: Number and Distribution at Neuromuscular Junctions in Rat Diaphragm

Douglas M. Fambrough 1 and H. Criss Hartzell 2

1 Department of Embryology, Carnegie Institution of Washington, Baltimore, Maryland 21210
2 Department of Biology, Johns Hopkins University, Baltimore 21218

The number of acetylcholine receptors per motor end plate in the rat diaphragm, measured by the binding of [1251]agr-bungarotoxin, varies directly with rat size and is (4.0 ± 0.2) x 107 for full-grown male rats. Autoradiographic analysis of single fibers labeled with this substance reveals that virtually all of these receptors are localized in the end plate.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Identification of Nicotinic Acetylcholine Receptor Recycling and Its Role in Maintaining Receptor Density at the Neuromuscular Junction In Vivo.
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Rapid and Reversible Effects of Activity on Acetylcholine Receptor Density at the Neuromuscular Junction in Vivo.
M. Akaaboune, S. M. Culican, S. G. Turney, and J. W. Lichtman (1999)
Science 286, 503-507
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ACh receptor-rich membrane domains organized in fibroblasts by recombinant 43-kildalton protein.
W. Phillips, C Kopta, P Blount, P. Gardner, J. Steinbach, and J. Merlie (1991)
Science 251, 568-570
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The Number of Acetylcholine Molecules in a Quantum and the Interaction between Quanta at the Subsynaptic Membrane of the Skeletal Neuromuscular Synapse.
H. C. Hartzell, S. W. Kuffler, and D. Yoshikami (1976)
Cold Spring Harb Symp Quant Biol 40, 175-186
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Some Structural Properties of the Cholinergic Receptor Protein in Its Membrane Environment Relevant to Its Function as a Pharmacological Receptor.
J.-P. Changeux, L. Benedetti, J.-P. Bourgeois, A. Brisson, J. Cartaud, P. Devaux, H. Grunhagen, M. Moreau, J.-L. Popot, A. Sobel, et al. (1976)
Cold Spring Harb Symp Quant Biol 40, 211-230
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Control of ACh Sensitivity in Rat Muscle Fibers.
T. Lomo and R. H. Westgaard (1976)
Cold Spring Harb Symp Quant Biol 40, 263-274
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Synapse Formation and Neurotrophic Effects on Muscle Cell Lines.
Y. Kidokoro, S. Heinemann, D. Schubert, B. L. Brandt, and F. G. Klier (1976)
Cold Spring Harb Symp Quant Biol 40, 373-388
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Fate of agr-Bungarotoxin Bound to Acetylcholine Receptors of Normal and Denervated Muscle.
D. K. Berg and Z. W. Hall (1974)
Science 184, 473-475
   Abstract »    PDF »
Neuromuscular Junction in Myasthenia Gravis: Decreased Acetylcholine Receptors.
D. M. Fambrough, D. B. Drachman, and S. Satyamurti (1973)
Science 182, 293-295
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Science. ISSN 0036-8075 (print), 1095-9203 (online)