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Science 14 April 1972:
Vol. 176. no. 4031, pp. 182 - 184
DOI: 10.1126/science.176.4031.182
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Articles

Organotypic Bioelectric Activity in Cultured Reaggregates of Dissociated Rodent Brain Cells

Stanley M. Crain 1 and Murray B. Bornstein 1

1 Departments of Physiology and Neurology, Albert Einstein College of Medicine, and Rose F. Kennedy Center for Research in Mental Retardation and Human Development, Bronx, New York 10461

Complex repetitive-spike or slow-wave discharges can be evoked, and can also occur spontaneously, in small clusters of neurons which reaggregate in vitro after dissociation of cerebral cortex, brainstem, or spinal cord from the fetal mouse. Even after random dispersion in culture, these cells still form functional synaptic networks with bioelectric discharge patterns and pharmacologic sensitivities characteristic of the organ (that is, organotypic).


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Development of specific sensory-evoked synaptic networks in fetal mouse cord-brainstem cultures.
S. Crain and E. Peterson (1975)
Science 188, 275-278
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Science. ISSN 0036-8075 (print), 1095-9203 (online)