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Science 14 April 1972:
Vol. 176. no. 4031, pp. 170 - 171
DOI: 10.1126/science.176.4031.170
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Articles

The Immune Reaction as a Stimulator of Tumor Growth

Richmond T. Prehn 1

1 Institute for Cancer Research, 7701 Burholme Avenue, Philadelphia, Pennsylvania 19111

Various numbers of spleen cells from specifically immunized mice were mixed with constant numbers of target tumor cells, and were inoculated subcutaneously into thymectomized, x-irradiated recipients. Small numbers of admixed immune spleen cells produced a statistically significant, and reproducible, acceleration of tumor growth in the inoculum as compared with controls of either nonimmune spleen cells or spleen cells from animals immune to a different, non-cross-reacting, tumor. Larger. numbers of specifically immune spleen cells, however, produced inhibition of tumor growth. These data imply that the normal immune reaction may have a dual function in relation to neoplasia: (i) stimulation of tumor growth, early in the course of the disease, or whenever the immune reaction is minimal; (ii) inhibition of tumor growth at other times.


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