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Science 7 April 1972:
Vol. 176. no. 4030, pp. 71 - 73
DOI: 10.1126/science.176.4030.71
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Articles

The Chimpanzee as an Animal Model for Investigating Alcoholism

W. A. Pieper 1, Marianne J. Skeen 2, Harold M. McClure 2, and Peter G. Bourne 3

1 Yerkes Regional Primate Research Center, Emory University, Atlanta, Georgia 30322, and Department of Psychology, Georgia State University, Atlanta 30303
2 Yerkes Regional Primate Research Center, Emory University, Atlanta, Georgia 30322
3 Department of Psychiatry, Emory University, Atlanta, Georgia 30322

Young chimpanzees (Pan troglodytes) will accept ethanol in quantities sufficient to produce symptoms of withdrawal when ethanol is subsequently discontinued. Mild to severe symptoms of physical dependence, including grand mal seizures, are observed when ethanol is abruptly withdrawn after 6 to 10 weeks of chronic oral intake. In addition, the rate of disappearance of ethanol in blood increased during periods of chronic ingestion, an indication of developing metabolic tolerance. These results suggest that the young chimpanzee may be a suitable model for experimental studies of alcoholism.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Suppression by 1,3-butanediol of the ethanol withdrawal syndrome in rats.
E Majchrowicz, W. Hunt, and C Piantadosi (1976)
Science 194, 1181-1182
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Science. ISSN 0036-8075 (print), 1095-9203 (online)