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Science 7 April 1972:
Vol. 176. no. 4030, pp. 55 - 56
DOI: 10.1126/science.176.4030.55
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Articles

Immunoglobulin M: Fixation of Human Complement by the Fc Fragment

Andrew G. Plaut 1, Stanley Cohen 1, and Thomas B. Tomasi Jr. 1

1 Departments of Medicine and Pathology, State University of New York at Buffalo, Meyer Memorial Hospital, Buffalo 14215

The Fc fragment [(Fc)5µ with a molecular weight of 342,000] of human immunoglobulin M from patients with Waldenström's macroglobulinemia has a complement fixing ability approximately 19 times greater on a molar basis than that of the parent immunoglobulin M. This fragment, which occurs naturally as a pentamer fixes human but not guinea pig complement, and this activity remains unchanged even after the fragment is reduced to the monomeric form.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Complete Amino Acid Sequence of the Mu Heavy Chain of a Human IgM Immunoglobulin.
F. W. Putnam, G. Florent, C. Paul, T. Shinoda, and A. Shimizu (1973)
Science 182, 287-291
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Science. ISSN 0036-8075 (print), 1095-9203 (online)