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Science 31 March 1972:
Vol. 175. no. 4029, pp. 1467 - 1468
DOI: 10.1126/science.175.4029.1467
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Articles

Expression of the Mammalian X Chromosome before and after Fertilization

Charles J. Epstein 1

1 Department of Pediatrics and Department of Biochemistry and Biophysics, University of California, San Francisco, 94122

The activity of hypoxanthine-guanine phosphoribosyltransferase in unfertilized mouse ova and in mouse embryos at the two-cell stage is proportional to the number of X chromosomes present during oogenesis. This indicates that the enzyme is X-linked in the mouse and that inactivation of the X chromosome does not occur during oogenesis. However, the genetic dosage effect of the X chromosomes is not present after the increase in hypoxanthine-guanine phosphoribosyltransferase activity in the late morula and the blastocyst stages. These results indicate that the X-linked enzyme lacuts is expressed sometimne after fertilization but before the morula stage.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The unique transcriptome through day 3 of human preimplantation development.
A. T. Dobson, R. Raja, M. J. Abeyta, T. Taylor, S. Shen, C. Haqq, and R. A. R. Pera (2004)
Hum. Mol. Genet. 13, 1461-1470
   Abstract »    Full Text »    PDF »
Imprinting of phosphoribosyltransferases during preimplantation development of the mouse mutant, Hprtb-m3.
T. Moore and D. Whittingham (1992)
Development 115, 1011-1016
   Abstract »    PDF »


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