Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 31 March 1972:
Vol. 175. no. 4029, pp. 1467 - 1468
DOI: 10.1126/science.175.4029.1467
Prev | Table of Contents | Next

Articles

Expression of the Mammalian X Chromosome before and after Fertilization

Charles J. Epstein 1

1 Department of Pediatrics and Department of Biochemistry and Biophysics, University of California, San Francisco, 94122

The activity of hypoxanthine-guanine phosphoribosyltransferase in unfertilized mouse ova and in mouse embryos at the two-cell stage is proportional to the number of X chromosomes present during oogenesis. This indicates that the enzyme is X-linked in the mouse and that inactivation of the X chromosome does not occur during oogenesis. However, the genetic dosage effect of the X chromosomes is not present after the increase in hypoxanthine-guanine phosphoribosyltransferase activity in the late morula and the blastocyst stages. These results indicate that the X-linked enzyme lacuts is expressed sometimne after fertilization but before the morula stage.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The unique transcriptome through day 3 of human preimplantation development.
A. T. Dobson, R. Raja, M. J. Abeyta, T. Taylor, S. Shen, C. Haqq, and R. A. R. Pera (2004)
Hum. Mol. Genet. 13, 1461-1470
   Abstract »    Full Text »    PDF »
Imprinting of phosphoribosyltransferases during preimplantation development of the mouse mutant, Hprtb-m3.
T. Moore and D. Whittingham (1992)
Development 115, 1011-1016
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)