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Science 24 March 1972:
Vol. 175. no. 4028, pp. 1380 - 1382
DOI: 10.1126/science.175.4028.1380
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Articles

Biogenic Amine Metabolites in Cerebrospinal Fluid of Depressed and Manic Patients

J. Mendels 1, A. Frazer 1, R. G. Fitzgerald 1, T. A. Ramsey 1, and J. W. Stokes 1

1 Department of Psychiatry and Pharmacology, University of Pennsylvania; Veterans Administration Hospital, Philadelphia

A reduction in 5-hydroxyindoleacetic acid in cerebrospinal fluid was found in depressed and manic patients both while they were symptomatic and also after treatment. The concentration of homovanillic acid was initially reduced and then tended to increase after treatment.


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Science. ISSN 0036-8075 (print), 1095-9203 (online)