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Science 24 March 1972:
Vol. 175. no. 4028, pp. 1373 - 1375
DOI: 10.1126/science.175.4028.1373
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Articles

Acetylcholine:Possible Neuromuscular Transmitter in Crustacea

Kin J. Futamachi 1

1 Department of Neurology, Stanford University School of Medicinie, Stanford, California 94305

The tonic flexor muscles of the crayfish abdomen respond with a large depolarizing potential to acetylcholine iontophoresed onto a neuromuscular Junction, but not to glutamate. Excitatory junctional potentials are abolished by d-tubocurarine and enhanced by a cholinesterase inhibitor. The membrane is depolarized and the junctional potentials are desensitized by excess acetylcholine. Thus acetylcholine is thought to be the neuromuscular transmitter.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)