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Science 24 March 1972:
Vol. 175. no. 4028, pp. 1372 - 1373
DOI: 10.1126/science.175.4028.1372
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Articles

Oxygen Affinity in Red Cells: Changes Induced in vivo by Propranolol

Frank A. Oski 1, Leonard D. Miller 1, Maria Delivoria-Papadopoulos 1, Joel H. Manchester 1, and James C. Shelburne 1

1 University of Pennsylvania, School of Medicine, Philadelphia 19104

Propranolol, a blocking agent for the beta adrenergic receptor, produces a redistribution of 2,3-diphosphoglycerate in the red cell. At concentrations of 3.3 x10-5M, 2,3-diphosphoglycerate in the red cell membrane becomes unbound in vitro. The administration of propranolol to hunmns produces similar changes and results in a decrease in the affinity of hemoglobin for oxygen.


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