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Science 24 March 1972:
Vol. 175. no. 4028, pp. 1368 - 1370
DOI: 10.1126/science.175.4028.1368
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Articles

Galactose Utilization in Galactosemia

John C. Petricciani 1, Marc K. Binder 1, Carl R. Merril 2, and Mark R. Geiter 2

1 Division of Biologics Standards, National Institutes of Health, Bethesda, Maryland 20014
2 Laboratory of General and Comparative Biochemistry, National Institute of Mental Health, Bethesda, Maryland 20014

Cultures of human galactosemic fibroblasts without detectable transferase activity were able to convert [1-14C]galactose to 14CO2 to the same extent as normal cells, but did so at a significantly slower rate. The utilization of galactose in both normal and galactosemic cells was strongly inhibited by glucose at physiologic concentrations.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Galactosemia and Galactonolactone: Further Biochemical Observations.
T. B. Friedman, R. J. Yarkin, C. R. Merril, H. Z. Hill, and C.-Y. Young (1974)
Science 183, 764-766
   PDF »
Detection of Inborn Errors of Metabolism: Galactosemia.
H. Z. Hill and T. T. Puck (1973)
Science 179, 1136-1139
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)