Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 24 March 1972:
Vol. 175. no. 4028, pp. 1365 - 1366
DOI: 10.1126/science.175.4028.1365
Prev | Table of Contents | Next

Articles

Psychotomimetic N-Methylated Tryptamines: Formation in Brain in vivo and in vitro

Juan M. Saavedra 1 and Julius Axelrod 1

1 Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20014

The use of a sensitive enzymatic assay demonstrates that tryptamine occurs normally in rat brain. Intracisternal administration of [14C]tryptamine results in the formation of N-methyl-and dimethyltryptamine(a psychotomimetic compound)in the rat brain. An enzyme that converts tryptamine and N-methyl-tryptamine to N-methyl-and dimethyltryptamine was found to be present in rat and human brain. The N-methylation of tryptamine was inhibited by normally occurring compounds present in rat brain.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
When the Endogenous Hallucinogenic Trace Amine N,N-Dimethyltryptamine Meets the Sigma-1 Receptor.
T.-P. Su, T. Hayashi, and D. B. Vaupel (2009)
Science Signaling 2, pe12
   Abstract »    Full Text »    PDF »
The Hallucinogen N,N-Dimethyltryptamine (DMT) Is an Endogenous Sigma-1 Receptor Regulator.
D. Fontanilla, M. Johannessen, A. R. Hajipour, N. V. Cozzi, M. B. Jackson, and A. E. Ruoho (2009)
Science 323, 934-937
   Abstract »    Full Text »    PDF »
Rabbit Lung Indolethylamine N-Methyltransferase. cDNA AND GENE CLONING AND CHARACTERIZATION.
M. A. Thompson and R. M. Weinshilboum (1998)
J. Biol. Chem. 273, 34502-34510
   Abstract »    Full Text »    PDF »
Increased Excretion of Dimethyltryptamine and Certain Features of Psychosis: A Possible Association.
R. M. Murray, M. C. H. Oon, R. Rodnight, J. L. T. Birley, and A. Smith (1979)
Arch Gen Psychiatry 36, 644-649
   Abstract »    PDF »
Tryptoline formation by a preparation from brain with 5-methyltetrahydrofolic acid and tryptamine.
R. Wyatt, E Erdelyi, DoAmaral JR, G. Elliott, J Renson, and J. Barchas (1975)
Science 187, 853-855
   Abstract »    PDF »
Drugs, Neurotransmitters, and Schizophrenia.
S. H. Snyder, S. P. Banerjee, H. I. Yamamura, and D. Greenberg (1974)
Science 184, 1243-1253
   PDF »
Behavioral Changes of Chronic Schizophrenic Patients Given L-5-Hydroxytryptophan.
R. J. Wyatt, T. Vaughan, M. Galanter, J. Kaplan, and R. Green (1972)
Science 177, 1124-1126
   Abstract »    PDF »
Indole-3-Acetic Acid in-Human Cerebrospinal Fluid: Identification and Quantification by Mass Fragmentography.
L. Bertilsson and L. Palmer (1972)
Science 177, 74-76
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)