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Science 24 March 1972:
Vol. 175. no. 4028, pp. 1363 - 1364
DOI: 10.1126/science.175.4028.1363
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Articles

Digitonin Effects on Photoreceptor Adenylate Cyclase

M. W. Bitensky 1, R. E. Gorman 1, and W. H. Miller 2

1 Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06510
2 Department of Ophthalmology, Yale University School of Medicine

Adenylate cyclase is described in a number of photoreceptor membranes. Vertebrate rod outer segments contain light-regulated cyclase, and light regulation is abolished by digitonin. Disruption of microvilli in cone and rhabdomphotoreceptors is also associated with loss of light regulation and retention of full enzymic activity. The data suggest that inhibitory constraint provides regulation in cyclase systems and that disruption of membrane structure uncouples catalytic and regulatory elements.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Control of Guanylate Cyclase Activity in the Rod Outer Segment.
R. G. Pannbacker (1973)
Science 182, 1138-1140
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Science. ISSN 0036-8075 (print), 1095-9203 (online)