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Science 10 March 1972:
Vol. 175. no. 4026, pp. 1140 - 1142
DOI: 10.1126/science.175.4026.1140
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Articles

Synaptic Transmission Depressed by Colchicine Blockade of Axoplasmic Flow

M. PerisacuteIcacute 1 and M. Cuénod 1

1 Brain Research Institute, August Forel Strasse 1, 8008 Zurich, Switzerland

Colchicine, which inhibits axoplasmic transport and induces organelle alterations in nerve terminals, was injected intraocularly in pigeons. Electrical stimulation of the optic nerve yielded normal evoked potentials in retinotectal fibers, whereas postsynaptic responses recorded in the tectum were reduced. Postsynaptic depression suggests a deficit of synaptic transmission, presumably dependent on colchicine interference with migrating material.


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Dystrophic Chicken Muscle: Altered Synaptic Acetylcholinesterase.
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Axotomy Mimicked by Localized Colchicine Application.
G. Pilar and L. Landmesser (1972)
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Science. ISSN 0036-8075 (print), 1095-9203 (online)