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Science 10 March 1972:
Vol. 175. no. 4026, pp. 1139 - 1140
DOI: 10.1126/science.175.4026.1139
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Articles

Intravascular Degranulation of Neutrophils: An Important Factor in Inflammation?

H. Ralph Schumacher 1 and Carlos A. Agudelo 1

1 206 Maloney Building, Hospital of the University of Pennsylvania, Philadelphia 19104

Polymorphonuclear leukocytes are degranulated in the lumens of vessels in synovial membrane in humans with various types of inflammatory arthritis and in dogs with synovitis induced by urate crystals. This degranulation, accompanied by the release of lysosomal enzymes and vasoactive materials, may be an important part of the mechanism resulting in vascular injury.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)