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Science 10 March 1972:
Vol. 175. no. 4026, pp. 1128 - 1130
DOI: 10.1126/science.175.4026.1128
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Articles

Pancreatic Beta-Cell Web: Its Possible Role in Insulin Secretion

L. Orci 1, K. H. Gabbay 2, and W. J. Malaisse 3

1 Institutes of Histology and Clinical Biochemistry, University of Geneva, Geneva, Switzerland, and Joslin Research Laboratory, Harvard Medical School, Boston, Massachusetts 02215
2 Children's Hospital Medical Center, Boston, Massachusetts 02215
3 Laboratory of Experimental Medicine, University of Brussels, Brussels, Belgium

A cortical band of fine microfilaments is consistently observed in the beta cells of the rat pancreas. Alteration of this cell web by cytochalasin B is associated with an enhancement of glucose-induced secretion of insulin by isolated islets. The microfilamentous web of the beta cell may play an important role in the emiocytosis of insulin secretory granules, by controlling their access to the cell membrane.


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