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Science 10 March 1972:
Vol. 175. no. 4026, pp. 1126 - 1128
DOI: 10.1126/science.175.4026.1126
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Articles

Thymus-Derived Lymphocytes: Humoral and Cellular Reactions Distinguished by Hydrocortisone

Shraga Segal 1, Irun R. Cohen 1, and Michael Feldman 1

1 Department of Cell Biology, Weizmann Institute of Science, Rehovot, Israel

Lymphocytes derived from the thymus (T cells) take part in the induction of humoral antibody and also effect cell-mediated graft-versus-host reactions. Preliminary treatment of mice with hydrocortisone caused an inhibition of T-cell function in humoral immunity, while enhancing the graft-versus-host reactivity of the same population of spleen cells. This suggests that different types of T cells participate in cellular and humoral immune reactions.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)