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Science 10 March 1972:
Vol. 175. no. 4026, pp. 1118 - 1121
DOI: 10.1126/science.175.4026.1118
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Articles

Electric Enhancement of Bone Healing

Leroy S. Lavine 1, Irving Lustrin 1, Robert A. Rinaldi 2, Morris H. Shamos 2, and Abraham R. Liboff 2

1 State University of New York, Downstate Medical Center, College of Medicine, New York
2 Biophysics Research Laboratory Department of Physics, New york University, New York 10003

A human congenital pseudarthrosis of the tibia, unresponsive to conventional treatment, was stimulated to healing by direct electric current. The method was modeled after prior experimental work in vivo in rabbits. X-ray photographs, histological techniques, and electron microscopy confirmed the presence of newly formed bone in the defect region.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Signal Transduction in Electrically Stimulated Bone Cells.
C. T. Brighton, W. Wang, R. Seldes, G. Zhang, and S. R. Pollack (2001)
J. Bone Joint Surg. Am. 83, 1514-1523
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DNA synthesis in cartilage cells is stimulated by oscillating electric fields.
G. Rodan, L. Bourret, and L. Norton (1978)
Science 199, 690-692
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Induced Collagenolytic Activity by Electrical Stimulation of Embryonic Fibroblasts in Tissue Culture.
B. B. Kamrin (1974)
Journal of Dental Research 53, 1475-1483
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Augmentation of Bone Repair by Inductively Coupled Electromagnetic Fields.
C. Andrew, L. Bassett, R. J. Pawluk, and A. A. Pilla (1974)
Science 184, 575-577
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Science. ISSN 0036-8075 (print), 1095-9203 (online)