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Science 3 March 1972:
Vol. 175. no. 4025, pp. 996 - 997
DOI: 10.1126/science.175.4025.996
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Articles

Tolerance to Sheep Red Cells: Breakage with Thymocytes and Horse Red Cells

Richard K. Gershon 1 and Kazunari Kondo 1

1 Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06510

Mice rendered tolerant to sheep red cells and then given normal thymocytes, made no antibody when immunized with these cells. When immunized with horse red blood cells, however, they made significant amounts of noncross-reacting antibody to sheep red blood cells. This suggests that antibody-making precursor cells (B cells) which are nontolerant but nonactivatable by specific antigen, may exist in tolerant hosts.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Specific Suppression of Immune Responses.
D. A. Rowley, F. W. Fitch, F. P. Stuart, H. Kohler, and H. Cosenza (1973)
Science 181, 1133-1141
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Science. ISSN 0036-8075 (print), 1095-9203 (online)