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Science 3 March 1972:
Vol. 175. no. 4025, pp. 994 - 996
DOI: 10.1126/science.175.4025.994
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Articles

Thyroid Hormone Influence upon Lung Surfactant Metabolism

Ralph A. Redding 1, William H. J. Douglas 2, and Myron Stein 3

1 Pulmonary Division, Memorial Hospital, Pawtucket, Rhode Island 02860, and Brown University, Providence, Rhode Island
2 W. Alton Jones Cell Science Center, Lake Placid, New York 12946
3 Department of Medicine, Memorial Hospital, Pawtucket, and Brown University

Thyroid administration and thyroidectomy in the rat profoundly affect the morphological characteristics of the type II pneumonocyte and the quantitative harvest of lung surfactant obtained from alveolar washings. The correlation of the ultrastructural changes with quantitative alterations in lung surfactant is evidence that the lamellar bodies within this cell are the source of the surface-active phospholipids utilized at the air-liquid interphase of lung alveoli. Our findings suggest that in the rat, L-thyroxine may be a potent regulator of lung surfactant metabolism.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Triiodo-L-thyronine Rapidly Stimulates Alveolar Fluid Clearance in Normal and Hyperoxia-injured Lungs.
M. Bhargava, M. R. Runyon, D. Smirnov, J. Lei, T. J. Groppoli, C. N. Mariash, O. D. Wangensteen, and D. H. Ingbar (2008)
Am. J. Respir. Crit. Care Med. 178, 506-512
   Abstract »    Full Text »    PDF »
Dopamine versus dobutamine in very low birthweight infants: endocrine effects.
L. Filippi, M. Pezzati, C. Poggi, S. Rossi, A. Cecchi, and C. Santoro (2007)
Arch. Dis. Child. Fetal Neonatal Ed. 92, F367-F371
   Abstract »    Full Text »    PDF »
Thyroid Function in the Premature Infant.
D. A. FISHER (1977)
Arch Pediatr Adolesc Med 131, 842-844
   Abstract »    PDF »
Surfactant Secretion and Respiratory Distress Syndromes.
D. F. TIERNEY (1972)
Ann Intern Med 77, 652-653
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)